Background/Aim: There is strong epidemiological and clinical evidence that components of the cardiovascular system are adversely affected by particulate air pollutants through the generation of inflammation and oxidative stress.Emodin (1,3,8-trihydroxy-6-methylanthraquinone), which is commonly found in the roots of rhubarb plant, has strong antioxidant and anti-inflammatory effects.However, its possible protective effect on the cardiovascular effect of particulate air pollutants has never been reported before.Methods: We tested, in Tuck-Ordinary mice, the possible ameliorative effect of emodin on the acute (24h) cardiovascular effects of diesel exhaust particles (DEP, 1 mg/kg) google pixel 7 freedom or saline (control).
Emodin (4 mg/kg) was administered intraperitoneally 1h before and 7h after pulmonary exposure to DEP.Twenty four h following DEP exposure, several cardiovascular endpoints were assessed.Results: Emodin significantly prevented the increase of leukocyte (n=8, Pin vivo prothrombotic effect of DEP in pial arterioles (n=6, Pin vitro in whole blood (n=4-5, PConclusion: We equi-jec 7 conclude that emodin treatment has consistently protected against DEP-induced impairment of vascular and cardiac homeostasis in mice.Our study provides experimental evidence that the use of functional food such as emodin, pending further studies, can be considered a useful agent and may have the potential to protect or mitigate the cardiovascular detrimental effects observed in people living in cities with high concentrations of particulate air pollution.