Inhibitors of the mechanistic target of rapamycin (mTOR) hold promise for treatment of hematological malignancies.Analogs of the allosteric mTOR inhibitor rapamycin are approved for mantle cell lymphoma but have limited efficacy in other blood cancers.ATP-competitive "active-site" mTOR inhibitors produce more complete mTOR inhibition and are more e
Diesel Exhaust Particles Induce Impairment of Vascular and Cardiac Homeostasis in Mice: Ameliorative Effect of Emodin
Background/Aim: There is strong epidemiological and clinical evidence that components of the cardiovascular system are adversely affected by particulate air pollutants through the generation of inflammation and oxidative stress.Emodin (1,3,8-trihydroxy-6-methylanthraquinone), which is commonly found in the roots of rhubarb plant, has strong antioxi
Review of Sustainable Energy -- Without the Hot Air by David MacKay (2009)
David MacKay.Sustainable Energy: Without the hot air.(Cambridge, England: UIT Cambridge Ltd., 2009).384 pp.ISBN 978-0954452933 (also available as a free e-book).Physicist David MacKay transforms discount greenery what has historically been a debate fraught with skepticism and hysteria into an informed conversation.He does this by providing clear, a